Journal article

Reperfusion after 4-5 hours reduces infarct growth and improves clinical outcomes

Miguel R Picanco, Soren Christensen, Bruce CV Campbell, Leonid Churilov, Mark W Parsons, Patricia M Desmond, P Alan Barber, Christopher R Levi, Christopher F Bladin, Geoffrey A Donnan, Stephen M Davis

International Journal of Stroke | WILEY-BLACKWELL | Published : 2014

Abstract

BACKGROUND: The currently proven time window for thrombolysis in ischemic stroke is 4.5 h. Beyond this, the risks and benefits of thrombolysis are uncertain. AIMS: To determine whether thrombolysis and reperfusion were beneficial after 4.5 h, we examined clinical and radiological outcomes in patients treated with tissue plasminogen activator or placebo within 4.5-6 h, using data from the Echoplanar Imaging Thrombolytic Evaluation Trial. METHODS: In the Echoplanar Imaging Thrombolytic Evaluation Trial, ischemic stroke patients presenting three to six-hours after stroke onset were randomized to tissue plasminogen activator or placebo, without knowledge of magnetic resonance imaging results. Th..

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