Reperfusion after 4-5 hours reduces infarct growth and improves clinical outcomes
Miguel R Picanco, Soren Christensen, Bruce CV Campbell, Leonid Churilov, Mark W Parsons, Patricia M Desmond, P Alan Barber, Christopher R Levi, Christopher F Bladin, Geoffrey A Donnan, Stephen M Davis
International Journal of Stroke | WILEY-BLACKWELL | Published : 2014
BACKGROUND: The currently proven time window for thrombolysis in ischemic stroke is 4.5 h. Beyond this, the risks and benefits of thrombolysis are uncertain. AIMS: To determine whether thrombolysis and reperfusion were beneficial after 4.5 h, we examined clinical and radiological outcomes in patients treated with tissue plasminogen activator or placebo within 4.5-6 h, using data from the Echoplanar Imaging Thrombolytic Evaluation Trial. METHODS: In the Echoplanar Imaging Thrombolytic Evaluation Trial, ischemic stroke patients presenting three to six-hours after stroke onset were randomized to tissue plasminogen activator or placebo, without knowledge of magnetic resonance imaging results. Th..View full abstract
C. R. L., M. W. P., and C. F. B. have accepted honoraria or consultancy and travel grants from Boehinger-Ingelheim and Sanofi-Aventis.