MRI-identified pathology in adults with new-onset seizures
Tahir Hakami, Anne Mcintosh, Marian Todaro, Elaine Lui, Raju Yerra, K Meng Tan, Chris French, Simon Li, Patricia Desmond, Zelko Matkovic, Terence J O'Brien
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
OBJECTIVE: To determine the frequency and nature of potentially epileptogenic lesions on MRI in adults with new-onset seizures. METHODS: We prospectively studied a consecutive series of 993 patients (597 males [61%]; mean [SD] age: 42.2 [18.8] years, range 14.3-94.3 years) who presented to an adult First Seizure Clinic over a 10-year period. The MRI scans, performed clinically on 3- and 1.5-tesla scanners, were reviewed for their diagnostic yield, nature of abnormalities, and their association with abnormal electrical activity on EEG. RESULTS: MRI scans were acquired in 764 patients (77%); potentially epileptogenic lesions were detected in 177 (23%). The frequency of potentially epileptogeni..View full abstract
The study was funded by The Royal Melbourne Hospital Neuroscience Foundation and by the NHMRC Centre for Research Excellence in Translational Neuroscience.