Journal article

Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries

Maria D Van Kerkhove, Siddhivinayak Hirve, Artemis Koukounari, Anthony W Mounts



BACKGROUND: The global impact of the 2009 influenza A(H1N1) pandemic (H1N1pdm) is not well understood. OBJECTIVES: We estimate overall and age-specific prevalence of cross-reactive antibodies to H1N1pdm virus and rates of H1N1pdm infection during the first year of the pandemic using data from published and unpublished H1N1pdm seroepidemiological studies. METHODS: Primary aggregate H1N1pdm serologic data from each study were stratified in standardized age groups and evaluated based on when sera were collected in relation to national or subnational peak H1N1pdm activity. Seropositivity was assessed using well-described and standardized hemagglutination inhibition (HI titers ≥ 32 or ≥ 40) and m..

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University of Melbourne Researchers


Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

The authors would like to thank the many subjects who contributed in the individual studies and for the countries who were willing to share their pre-publication results to be included in this study. The authors would like to thank the following for their contributions to the initial studies in which data were shared for this meta-analysis: Ange Bissielo, Adam Meijer, Alessia Ranghiasci, Alexia Kieffer, Allison McGeer, Anette Kilander, Anne Kelso, Antoine Flahault, Anu Rebbapragada, Armelle Degeorges, Azzedine Assal, Beth Lowcock, Brian O'Toole, Brunhilde Schweiger, Bruno Lina, Caitlin Johnson, Camille Achonu, Carmen Yue, Ching-Chuan Liu, Chung-Ming Chang, Corey J. Crevar, Danielle Iuliano, David Irving, Dominic Dwyer, Don Willison, Donald M. Carter, Donald S. Burke, Emanuele Montomoli, Gerard Krause, Giulia Lapini, Graham Mackereth, Grethe H Krogh, Ian Johnson, Jacco Wallinga, Jacqueline Willmore, Jean-Paul Guthmann, Johan HJ Reimerink, Jonathan B Gubbay, Julie Foisy, Kate Goodin, Kathy Hancock, Klaus Stark, Laura Rosella, Linda Hueston, Maria Cristina Rota, Maria Grazia Caporali, Marianne AB van der Sande, Marie LaFreniere, Mariken van der Lubben, Marion Koopmans, Michael Baker, Michael Hohle, Michel Thamm, N Lapidus, Nicolas Salez, Panos Katerelos, Peter FM Teunis, Pierre Tiberghien, Rhonda Owen, Richard Beasley, Richard Hopkins, Sally Roberts, Sandra Waaijenborg, Shelley L Deeks, Silke Buda, Silvia Declich, Simona Piccirell, Steven Ostrof, Stewart Reid, Susanne G Dudman, Sylvie van der Werf, Tim Wood, Tony Mazzulli, Torstein Aune, Travis S Hottes, Valeria Alfonsi, Virginia Hope and YK Gurav. The authors would also like to thank the Health Policy Research Center in Iran and specifically, Dr K.B Lankarani. The authors would also like to acknowledge colleagues who shared data that did not meet our inclusion criteria: Theodore Tsai, Xiao-Feng Liang, Yu Wang, Fengcai Zhu, Laura Thompson and Salah Mahmud. The authors would like to thank Ben Cowling and Malik Peiris for their insight and advice on the analysis and interpretation of results. MDVK, AK, CAD, and NMF acknowledge funding from the Medical Research Council UK and the Bill and Melinda Gates Foundation (MDVK, NMF). AK is currently supported by an MRC Population Health Scientist Fellowship. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.