Journal article

FRAX provides robust fracture prediction regardless of socioeconomic status

SL Brennan, WD Leslie, LM Lix, H Johansson, A Oden, E McCloskey, JA Kanis

OSTEOPOROSIS INTERNATIONAL | SPRINGER LONDON LTD | Published : 2014

Abstract

UNLABELLED: We investigated the fracture risk assessment tool (FRAX) Canada calibration and discrimination according to income quintile in 51,327 Canadian women, with and without a competing mortality framework. Our data show that, under a competing mortality framework, FRAX provides robust fracture prediction and calibration regardless of socioeconomic status (SES). INTRODUCTION: FRAX® predicts 10-year fracture risk. Social factors may independently affect fracture risk. We investigated FRAX calibration and discrimination according to SES. METHODS: Women aged ≥50 years with baseline femoral neck bone mineral density (BMD) were identified from the Manitoba Bone Density Program, Canada (n = 5..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

The authors are indebted to Manitoba Health for the provision of data (HIPC file no. 2012/2013-15). The results and conclusions are those of the authors, and no official endorsement by Manitoba Health is intended or should be inferred. This article has been reviewed and approved by the members of the Manitoba Bone Density Program Committee. SL Brennan is supported by a National Health and Medical Research Council (NHMRC) of Australia Early Career Fellowship (1012472), and a 2012 Dyason Fellowship from The University of Melbourne. LM Lix is supported by a Manitoba Health Research Chair.