Journal article

Expression of the proangiogenic protein hepatoma-derived growth factor in neovessels in an arterial venous loop-based tissue engineering chamber

EC Chan, MH Tai, PC Wu, HM Kuo, F Jiang, R Tee, WA Morrison, GJ Dusting, GS Liu

Biomedical Engineering: Applications, Basis and Communications | Published : 2013

Abstract

Boosting angiogenesis is a crucial process to enhance tissue growth in tissue engineering (TE). Hepatoma-derived growth factor (HDGF) has been identified as an angiogenic factor, but its involvement in angiogenesis in an arteriovenous loop-based TE chamber developed by the laboratory is unclear. In this study, the authors first examined the effects of HDGF on angiogenic responses in endothelial cells and in a corneal model of neovascularization, and then characterized the expression of HDGF in the TE chamber. HDGF (1–500 ng/mL) induced concentration-dependent angiogenic responses in human endothelial cells in vitro (proliferation, migration, and tube formation). Local application of HDGF sti..

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