Journal article
Aortic Stiffness in Lone Atrial Fibrillation: A Novel Risk Factor for Arrhythmia Recurrence
DH Lau, ME Middeldorp, AG Brooks, AN Ganesan, KC Roberts-Thomson, MK Stiles, DP Leong, HS Abed, HS Lim, CX Wong, SR Willoughby, GD Young, JM Kalman, WP Abhayaratna, P Sanders
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Open access
Abstract
Background:Recent community-based research has linked aortic stiffness to the development of atrial fibrillation. We posit that aortic stiffness contributes to adverse atrial remodeling leading to the persistence of atrial fibrillation following catheter ablation in lone atrial fibrillation patients, despite the absence of apparent structural heart disease. Here, we aim to evaluate aortic stiffness in lone atrial fibrillation patients and determine its association with arrhythmia recurrence following radio-frequency catheter ablation.Methods:We studied 68 consecutive lone atrial fibrillation patients who underwent catheter ablation procedure for atrial fibrillation and 50 healthy age- and se..
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Funding Acknowledgements
Drs. Lau and Leong are supported by a Postdoctoral Fellowship from the National Health and Medical Research Council of Australia (NHMRC). Drs. Brooks, Roberts-Thomson and Sanders are supported by the Heart Foundation of Australia (HFA). Dr. Ganesan is supported by a CVL grant from Pfizer Australia. Dr. Abed is supported by an Australian Postgraduate Award and an Earl Bakken Fellowship from the University of Adelaide. Dr. Lim is supported by a Postgraduate Scholarship from NHMRC. Dr. Wong is supported by the Rhodes scholarship. Dr. Willoughby is supported by the NHMRC. This work is supported by an equipment grant from Tom Simpson Trust Fund, HFA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.