Journal article
Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches
CP Le, T Karnezis, MG Achen, SA Stacker, EK Sloan
Best Practice and Research Clinical Anaesthesiology | ELSEVIER | Published : 2013
Abstract
The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including immune cells, endothelial cells, cancer-associated fibroblasts and nerve fibres. These host cells contribute molecular signals that enhance primary tumour growth and provide physical avenues for metastatic dissemination. This article provides an overview of the role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment and highlights the interconnected molecular signalling pathways that control their development and activation in cancer. Further, this article highlights the known pharmacological agents which target these pathways and d..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
Marc G. Achen and Steven A. Stacker are supported by research fellowships and a Program Grant from the National Health and Medical Research Council of Australia. Erica K. Sloan is a National Breast Cancer Foundation Early Career Fellow and is supported by National Health and Medical Research Council of Australia (1008865 and 1049561), National Institutes of Health (CA160890), Monash Institute of Pharmaceutical Sciences and the UCLA Norman Cousins Center. Caroline P. Le is supported by a PhD scholarship from Cancer Therapeutics Co-operative Research Centre. We apologise to authors whose work could not be quoted due to space limitations.