Harnessing Genomic Technologies to Explore the Molecular Biology of Liver Flukes-Major Implications for Fundamental and Applied Research

Abstract

Liver flukes are socioeconomically important flatworms (Trematoda: Digenea) which parasitize the hepatobiliary systems of definitive mammalian hosts, including humans. Key representatives include Opisthorchis viverrini, Clonorchis sinensis (Opisthorchiidae), and Fasciola gigantica and Fasciola hepatica (Fasciolidae). Collectively, these parasites affect the health of tens of millions of humans and other animals throughout the world. F. hepatica and F. gigantica cause fascioliasis (= disease), leading to major production losses in livestock (mainly sheep and cattle) as a result of reduced weight gain and milk production, and mortality. Both fasciolids and opisthorchiids are important food-bor..