Journal article

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola Show all

Immunity | CELL PRESS | Published : 2013

Grants

Awarded by NHMRC


Awarded by NHMRC IRIISS


Funding Acknowledgements

We thank staff in the WEHI Bioservices facility, V. Dixit for Ripk3<SUP>-/-</SUP> mice, J. Rickard for generating Ripk3<SUP>-/-</SUP> MDFs, P. Colman and D. Huang for discussions, MX and SAXS beamline staff at the Australian Synchrotron, the Monash University Protein Production Unit for access to the Corbett RT-PCR instrument, and J. Corbin, L. DiRago, C. Hyland, S. Mifsud, D. Stockwell, and T. Willson for technical assistance. This work was supported by NHMRC grants (1016647, 461221, 1016701, 637342, 1025594, 1046984) and fellowships to J. M. H., I. J. M., D. J. H., N.A.N., A. S., J. S., and W. S. A.; ARC fellowships to J. M. M., P. E. C., T.O., and J. J. B.; a Cancer Council Victoria fellowship to D. M.; Leukaemia Foundation and Australian Stem Cell Centre scholarships to L.N.V.; and additional support from the Australian Cancer Research Fund, Victorian State Government Operational Infrastructure Support, and NHMRC IRIISS grant (361646).