Journal article
Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1)
A Arnott, I Mueller, PA Ramsland, PM Siba, JC Reeder, AE Barry
Plos Neglected Tropical Diseases | Published : 2013
Abstract
Background:The Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1) is a promising malaria vaccine candidate, however it remains unclear which regions are naturally targeted by host immunity and whether its high genetic diversity will preclude coverage by a monovalent vaccine. To assess its feasibility as a vaccine candidate, we investigated the global population structure of PvAMA1.Methodology and Principal Findings:New sequences from Papua New Guinea (PNG, n = 102) were analysed together with published sequences from Thailand (n = 158), India (n = 8), Sri Lanka (n = 23), Venezuela (n = 74) and a collection of isolates from disparate geographic locations (n = 8). A total of 92 single nucleot..
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Funding Acknowledgements
This work was supported by Project Grant 1003825 from the National Health and Medical Research Council (NHMRC) of Australia (http://www.nhmrc.gov.au). IM and JCR were supported by NHMRC Principal Research Fellowships. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS (http://grants.myregion.gov.au/grant/infrastructure-support-funding). The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.