Journal article
Chronic Administration of the Methylxanthine Propentofylline Impairs Reinstatement to Cocaine by a GLT-1-Dependent Mechanism
Kathryn J Reissner, Robyn M Brown, Sade Spencer, Phuong K Tran, Charles A Thomas, Peter W Kalivas
NEUROPSYCHOPHARMACOLOGY | NATURE PUBLISHING GROUP | Published : 2014
DOI: 10.1038/npp.2013.223
Abstract
In recent years, interactions between neurons and glia have been evaluated as mediators of neuropsychiatric diseases, including drug addiction. In particular, compounds that increase expression of the astroglial glutamate transporter GLT-1 (N-acetylcysteine and ceftriaxone) can decrease measures of drug seeking. However, it is unknown whether the compounds that influence broad measures of glial physiology can influence behavioral measures of drug relapse, nor is it clear whether the upregulated GLT-1 is functionally important for suppressing of drug seeking. To address these questions, we sought to determine whether the glial modulator and neuroprotective agent propentofylline (PPF) modifies..
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Funding Acknowledgements
The authors thank members of the Kalivas lab for helpful comments on a previous version of this manuscript. This work was supported by DA026254 (KJR), DA015369/DA003906 (PWK), and American Australian Association and NHMRC (RMB).