Journal article
The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial (STOP-AUST): Protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial
A Meretoja, L Churilov, BCV Campbell, RI Aviv, N Yassi, C Barras, P Mitchell, B Yan, H Nandurkar, C Bladin, T Wijeratne, NJ Spratt, J Jannes, J Sturm, J Rupasinghe, J Zavala, A Lee, T Kleinig, R Markus, C Delcourt Show all
International Journal of Stroke | SAGE PUBLICATIONS LTD | Published : 2014
DOI: 10.1111/ijs.12132
Abstract
Rationale: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions. Aim: The study aims to test the hypothesis that intracerebral hemorrhage patients selected with computed tomography angiography contrast extravasation 'spot sign' will have lower rates of hematoma growth when treated with intravenous tranexamic acid within 4·5-hours of stroke onset compared with placebo. Design: The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial is a multicenter, prospective, 1:1 randomized, double-blind, placebo-controlled..
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Funding Acknowledgements
Dr Meretoja has consulted for Boehringer Ingelheim. Dr Campbell has consulted for Lundbeck and received speaker's honoraria from Boehringer Ingelheim and Novartis. Dr Yan has received speaker's honoraria from Boehringer Ingelheim and educational grants from Bayer and CSL. Dr Nandurkar has consulted for Sanofi, Bayer, Pfizer, Alexion, GSK, and Hospira. Dr Sturm has received speaker's honoraria form Boehringer Ingelheim, Bayer, and Pfizer. Dr Markus has served on advisory board for Boehringer Ingelheim. Dr Levi served on advisory boards for Pfizer and Boehringer Ingelheim. Dr Donnan has consulted for Boehringer Ingelheim, Sanofi, Bayer, and Lundbeck. Dr Davis has served on advisory boards for Boehringer Ingelheim, Ever Pharma, and Sanofi-Aventis. He previously consulted for Novo Nordisk.