Tonic seizures of Lennox-Gastaut syndrome: Periictal single-photon emission computed tomography suggests a corticopontine network

U Intusoma; DF Abbott; RAJ Masterton; MR Stagnitti; MR Newton; GD Jackson; JL Freeman; A Simon Harvey; JS Archer

Journal article

Tonic seizures of Lennox-Gastaut syndrome: Periictal single-photon emission computed tomography suggests a corticopontine network

U Intusoma, DF Abbott, RAJ Masterton, MR Stagnitti, MR Newton, GD Jackson, JL Freeman, A Simon Harvey, JS Archer

Epilepsia | WILEY | Published : 2013

DOI: 10.1111/epi.12398

Abstract

Purpose Lennox-Gastaut syndrome (LGS) is a severe epileptic disorder with characteristic electroclinical features but diverse etiologies. The shared electroclinical characteristics suggest that common cerebral networks are involved in generating seizures. We sought to reveal these networks by comparing ictal and interictal single-photon emission computed tomography (SPECT). Methods We identified 10 ictal-interictal SPECT pairs from seven patients with LGS (median age 11 years; range 1-38) who were studied during video electroencephalography (EEG)-confirmed tonic seizures. We performed a voxel-wise comparison of ictal and interictal SPECT studies across the group. The evolution of blood flow ..

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University of Melbourne Researchers

David Abbott Author

Graeme Jackson Author

Simon Harvey Author

John Archer Author

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

The nuclear medicine departments of Austin Health and Royal Children's Hospital Melbourne provided access to the imaging data. Mr Aaron Warren assisted with manuscript preparation. Professor Philip Thompson provided neuroanatomic insights. Funding support was provided by the National Health and Medical Research Council of Australia (NHMRC - project grant ID no. 628725), and the Operational Infrastructure Support Program of the State Government of Victoria, Australia.