Journal article

Measurement of structural anisotropy in femoral trabecular bone using clinical-resolution CT images

Mariana E Kersh, Philippe K Zysset, Dieter H Pahr, Uwe Wolfram, David Larsson, Marcus G Pandy



Discrepancies in finite-element model predictions of bone strength may be attributed to the simplified modeling of bone as an isotropic structure due to the resolution limitations of clinical-level Computed Tomography (CT) data. The aim of this study is to calculate the preferential orientations of bone (the principal directions) and the extent to which bone is deposited more in one direction compared to another (degree of anisotropy). Using 100 femoral trabecular samples, the principal directions and degree of anisotropy were calculated with a Gradient Structure Tensor (GST) and a Sobel Structure Tensor (SST) using clinical-level CT. The results were compared against those calculated with t..

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University of Melbourne Researchers


Awarded by Australian Research Council

Funding Acknowledgements

We gratefully acknowledge the assistance from Prof. M. Pretterklieber from the Department of Applied Anatomy and Prof. F. Kainberger from the Department of Radiology, both from the Medical University of Vienna, and E. Dall'Ara, T. Gross from the Institute of Lightweight Design and Structural Biomechanics, Vienna University of Technology for providing, imaging and respectively processing the trabecular bone biopsies of the proximal femur. This work was supported by an Australian Research Council Discovery Projects Grant (DP1095366) and a Victorian Endowment for Science, Knowledge and Innovation Fellowship to M.G.P. Support from the University of Melbourne for a McKenzie Postdoctoral Fellowship to M.E.K. is also gratefully acknowledged.