Detection of quantitative trait loci in Bos indicus and Bos taurus cattle using genome-wide association studies
Sunduimijid Bolormaa, Jennie E Pryce, Kathryn E Kemper, Ben J Hayes, Yuandan Zhang, Bruce Tier, William Barendse, Antonio Reverter, Mike E Goddard
GENETICS SELECTION EVOLUTION | BMC | Published : 2013
BACKGROUND: The apparent effect of a single nucleotide polymorphism (SNP) on phenotype depends on the linkage disequilibrium (LD) between the SNP and a quantitative trait locus (QTL). However, the phase of LD between a SNP and a QTL may differ between Bos indicus and Bos taurus because they diverged at least one hundred thousand years ago. Here, we test the hypothesis that the apparent effect of a SNP on a quantitative trait depends on whether the SNP allele is inherited from a Bos taurus or Bos indicus ancestor. METHODS: Phenotype data on one or more traits and SNP genotype data for 10 181 cattle from Bos taurus, Bos indicus and composite breeds were used. All animals had genotypes for 729 ..View full abstract
Awarded by ARC
The authors acknowledge the funding from the former Cooperative Research Centre for Beef Genetic Technologies in Australia for this study and ARC project DPI093502. We would like to thank CM Reich and BA Mason (Department of Primary Industries (DPI), Bundoora, VIC 3083, Australia) and RJ Bunch and BE Harrison (CSIRO Animal, Food and Health Sciences, Queensland Bioscience Precinct, St. Lucia, QLD 4067, Australia) for their work on genotyping. Also we are grateful to K Savin (DPI, Bundoora, VIC) for organising the genotype sets to be used and D Jonhston and HU Graser (Animal Genetics and Breeding Unit, Armidale, NSW 2351, Australia) for providing the phenotype sets.