Journal article

Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets

Nuzhat Ahmed, Khalid Abubaker, Jock K Findlay

MOLECULAR ASPECTS OF MEDICINE | ELSEVIER | Published : 2014

Abstract

In spite of recent progress in cancer therapeutics and increased knowledge about the cellular and molecular biology of cancer, ovarian cancer still remains a clinical challenge. Chemoresistance followed by tumor recurrence are major causes of poor survival rates of ovarian cancer patients. In recent years, ovarian cancer has been described as a stem cell disease. In this scenario, a small percentage of ovarian tumor cells with cancer stem cell-like properties should survive therapeutic treatments by activating the self-renewal and differentiating pathways resulting in tumor progression and clinical recurrence. The mere concept that a small subset of cells in the tumor population drives tumor..

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