Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets
Nuzhat Ahmed, Khalid Abubaker, Jock K Findlay
MOLECULAR ASPECTS OF MEDICINE | ELSEVIER | Published : 2014
In spite of recent progress in cancer therapeutics and increased knowledge about the cellular and molecular biology of cancer, ovarian cancer still remains a clinical challenge. Chemoresistance followed by tumor recurrence are major causes of poor survival rates of ovarian cancer patients. In recent years, ovarian cancer has been described as a stem cell disease. In this scenario, a small percentage of ovarian tumor cells with cancer stem cell-like properties should survive therapeutic treatments by activating the self-renewal and differentiating pathways resulting in tumor progression and clinical recurrence. The mere concept that a small subset of cells in the tumor population drives tumor..View full abstract
The authors wish to thank Women's Cancer Foundation for supporting this work. KA is a recipient of an Australian Postgraduate Award. The authors wish to acknowledge and thank Ms Francois Dobill for her ELISA data and Dr Rod Luwor for his help with the animal experiments.