Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: Results from a subset of the ladis study

MD Macfarlane; JCL Looi; M Walterfang; G Spulber; D Velakoulis; M Styner; M Crisby; E Örndahl; T Erkinjuntti; G Waldemar; E Garde; MG Hennerici; H Bäzner; C Blahak; A Wallin; LO Wahlund; T Pohjasvaara; P Pihanen; R Ylikoski; H Jokinen; MM Somerkoski; R Mäntylä; O Salonen; F Fazekas; R Schmidt; S Ropele; B Rous; K Petrovic; U Garmehi; A Seewann; JM Ferro; A Verdelho; S Madureira; C Moleiro; P Scheltens; I Van Straaten; F Barkhof; A Gouw; W Van Der Flier; M Jonsson; K Lind; A Nordlund; S Rolstad; I Isblad; A Pettersson; K Amberla; H Chabriat; K Hernandez; A Kurtz; D Herveacute; S Benisty; JP Guichard; H Baezner; M Wiarda; S Seip; E Rostrup; C Ryberg; T Dyrby; OB Paulson; KS Frederiksen; J O'Brien; S Pakrasi; M Krishnan; A Teodorczuk; M Firbank; T Minett; D Inzitari; L Bartolini; AM Basile; E Magnani; M Martini; M Mascalchi; M Moretti; L Pantoni; A Poggesi; G Pracucci; E Salvadori; M Simoni

Journal article

Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: Results from a subset of the ladis study

MD Macfarlane, JCL Looi, M Walterfang, G Spulber, D Velakoulis, M Styner, M Crisby, E Örndahl, T Erkinjuntti, G Waldemar, E Garde, MG Hennerici, H Bäzner, C Blahak, A Wallin, LO Wahlund, T Pohjasvaara, P Pihanen, R Ylikoski, H Jokinen Show all

American Journal of Geriatric Psychiatry | Published : 2015

DOI: 10.1016/j.jagp.2013.04.011

Abstract

Objective Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction. Methods Magnetic resonance imaging scans and clinical gait/balance data (scores from the Short Physical Performance Battery [SPPB]) were sourced from 66 subjects in the previously published LADIS trial, performed in ..

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University of Melbourne Researchers

Mark Walterfang Author

Dennis Velakoulis Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was supported by the European Union (grant QLRT-2000-00446, Impact of age-related brain white matter hyperintensities on transition to disability in the elderly "Leukoaraiosis and Disability"). The Danish cohort study was supported, in part, by the Danish Velux Foundation. JCLL self-funded travel costs to assist in conduct of this research in Melbourne and Stockholm. This research has made use of the SMILE medical imaging laboratory at Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden. MS was supported by National Institutes of Health grant U54 EB005149, National Alliance for Medical Image Computing (NA-MIC).