Networks underlying paroxysmal fast activity and slow spike and wave in Lennox-Gastaut syndrome
Neelan Pillay, John S Archer, Radwa AB Badawy, Danny F Flanagan, Samuel F Berkovic, Graeme Jackson
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
OBJECTIVE: To use EEG-fMRI to determine which structures are critically involved in the generation of paroxysmal fast activity (PFA) and slow spike and wave (SSW) (1.5-2.5 Hz), the characteristic interictal discharges of Lennox-Gastaut syndrome (LGS). METHODS: We studied 13 well-characterized patients with LGS using structural imaging and EEG-fMRI at 3 tesla. Ten patients had cortical structural abnormalities. PFA and SSW were considered as separate events in the fMRI analysis. RESULTS: Simultaneous with fMRI, PFA was recorded in 6 patients and SSW in 9 (in 2, both were recorded). PFA events showed almost uniform increases in blood oxygen level-dependent (BOLD) signal in "association" cortic..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by NHMRC
Supported by the National Health and Medical Research Council of Australia Program grant (628952) and an NHMRC practitioner fellowship to G.J. (527800), NHMRC Project grants 368650, 318900, 628725, and the Operational Infrastructure Support Program of the State Government of Victoria, Australia.