Journal article

Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells

Jessica A Pane, Nicole L Webster, Christel Zufferey, Barbara S Coulson



Rotavirus infection has been proposed to enhance progression towards type 1 diabetes in at-risk children. Rhesus monkey rotavirus (RRV) accelerates diabetes onset in non-obese diabetic (NOD) and T cell receptor transgenic NOD8.3 mice. Infected NOD mice show virus spread to pancreatic lymph nodes (PLN) and mesenteric lymph nodes (MLN), induction of a serum T helper 1-biased specific antibody response and proinflammatory cytokine mRNA expression in PLN and islets. Here, we analysed the effects of RRV infection on intestinal responses and the activation of antigen presenting cells (APC), T cells and B cells in PLN, MLN, spleen and islets. Diabetes acceleration by RRV was associated with minimal..

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Awarded by National Health and Medical Research Council of Australia

Awarded by Juvenile Diabetes Research Foundation

Funding Acknowledgements

We thank Gavan Holloway and Fiona Fleming for their expert experimental assistance, and David Taylor and Rhiannon Hall for mouse husbandry. This work was supported by Project Grants (509008 and 1044868) and a Senior Research Fellowship (628319) to B.S.C. from the National Health and Medical Research Council of Australia, and by Juvenile Diabetes Research Foundation Award 27-2011-281 to B.S.C.