Involvement of Nox2 NADPH oxidase in retinal neovascularization

EC Chan; P van Wijngaarden; GS Liu; F Jiang; H Peshavariya; GJ Dusting

Journal article

Involvement of Nox2 NADPH oxidase in retinal neovascularization

EC Chan, P van Wijngaarden, GS Liu, F Jiang, H Peshavariya, GJ Dusting

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2013

DOI: 10.1167/iovs.13-12883

Abstract

Purpose: The proliferation of new blood vessels in the retina is a leading cause of vision impairment. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) is involved in cell signaling for ischemia-induced angiogenesis, but its role in retinal neovascularization is unclear. We have analyzed the dependence of retinal neovascularization on the Nox2 isoform in oxygen-induced retinopathy (OIR) in mice.Methods: Neonatal C57BL/6 mice aged 7 days (P7) were placed in a hyperoxic chamber (75% O2) for 5 days, followed by 5 days of exposure to room air. Eyes were harvested on P8 and P17 for the quantification of retinal vaso-obliteration and neovascularization, respectively. The retinal e..

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University of Melbourne Researchers

Elsa Chan Author

Peter Van Wijngaarden Author

Rick Liu Author

Gregory Dusting Author

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC of Australia

Awarded by Natural Science Foundation of China

Funding Acknowledgements

Supported by National Health and Medical Research Council of Australia (NHMRC Grant 566911), by The Ansell Ophthalmology Foundation (ECC, G-SL), by fellowship support from the NHMRC of Australia (PF 11M 6093; PvW), and the National Heart Foundation of Australia (HP), by a Principal Research Fellowship of the NHMRC of Australia (GJD), and by Grant 81070164 from Natural Science Foundation of China (FJ).