Journal article

Rapid blood clearance and lack of long-term renal toxicity of Lu-177-DOTATATE enables shortening of renoprotective amino acid infusion

Raghava Kashyap, Price Jackson, Michael S Hofman, Peter Eu, Jean-Mathieu Beauregard, Diana Zannino, Rodney J Hicks

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | SPRINGER | Published : 2013

Abstract

PURPOSE: The aim of the study was to investigate the feasibility of shortening the recommended 4-h renoprotective amino acid infusion in patients receiving peptide receptor chemoradionuclide therapy (PRCRT) using radiosensitizing 5-fluorouracil. We evaluated the clearance of radiopeptide from the blood, long-term nephrotoxicity in patients undergoing PRCRT with the conventional 4-h amino acid infusion and renal uptake in patients receiving an abbreviated infusion. METHODS: The whole-blood clearance of (177)Lu-DOTA-octreotate (LuTate) was measured in 13 patients receiving PRCRT. A retrospective analysis of short-term and long-term changes in glomerular filtration rate (GFR) in 96 consecutive ..

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Grants

Funding Acknowledgements

Professor Hicks and Dr. Jackson were supported by a Translational Research Grant from the Victorian Cancer Agency. Dr. K Raghava Kashyap was supported by Endeavour Awards, a venture of Austraining International in partnership with the Department of Education, Employment and Workplace Relations, Government of Australia. We acknowledge the support and inspiration provided to our facility over the past 15 years from the Department of Nuclear Medicine at the Erasmus Medical Centre under the leadership of Professor Eric Krenning.