Abnormal left ventricular diastolic function at late follow-up after repair of total anomalous pulmonary venous drainage: The impact of altered ventricular loading in utero

Abstract

Background Assessment of diastolic function has not been described after repair of total anomalous pulmonary venous drainage (TAPVD), but studies of exercise capacity demonstrate impaired performance in this population despite normal systolic function. We postulated that diastolic impairment might contribute to this finding. Methods We analyzed echocardiographic variables from 28 patients with repaired TAPVD and compared these with data from 32 healthy controls (normals) and 21 subjects with repaired transposition of the great arteries (TGA). Results Left ventricular (LV) end-diastolic volumes were smaller in the TAPVD group (median, 50 mL/m2 compared with a median of 64 mL/m2 in TGA and 67 ..