Early Cochlear Response and ICAM-1 Expression to Cochlear Implantation
Gordana Elizabeth Kel, Justin Tan, Hayden Timothy Eastwood, Sarin Wongprasartsuk, Stephen John O'Leary
OTOLOGY & NEUROTOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
AIM: To examine the early cochlear response and intercellular cell adhesion molecule-1 (ICAM-1) expression to implantation of a cochlear electrode into the scala tympani. BACKGROUND: Understanding the early response of the cochlea to implantation may inform the duration which drug therapies should be delivered to protect hearing. METHODS: Guinea pigs were implanted with a cochlear electrode and survived 1, 2, or 7 days before they were euthanized, cochleae harvested, processed, and cryosectioned for light microscopy or ICAM-1 immunohistochemistry. RESULTS: On hematoxylin and eosin staining, scala tympani was characterized by the presence of fibrin and blood clot at 1 to 2 days after surgery,..View full abstract
Funding support: Garnett Passe and Rodney Williams Memorial Foundation, Australian National Health and Medical Research Council.