Early cochlear response and ICAM-1 expression to cochlear implantation

Abstract

Aim: To examine the early cochlear response and intercellular cell adhesion molecule-1 (ICAM-1) expression to implantation of a cochlear electrode into the scala tympani. Background: Understanding the early response of the cochlea to implantation may inform the duration which drug therapies should be delivered to protect hearing. Methods: Guinea pigs were implanted with a cochlear electrode and survived 1, 2, or 7 days before they were euthanized, cochleae harvested, processed, and cryosectioned for light microscopy or ICAM-1 immunohistochemistry. Results: On hematoxylin and eosin staining, scala tympani was characterized by the presence of fibrin and blood clot at 1 to 2 days after surgery,..