No change in calreticulin with fetal growth restriction in human and rat pregnancies

Abstract

Introduction Calreticulin is a ubiquitously expressed protein that was detected in the circulation and is significantly increased in maternal blood during human pregnancy compared to the non-pregnant state. Calreticulin is further increased in the plasma of women with the pregnancy-related disorder pre-eclampsia compared to normotensive pregnancy. The aims of this study were to compare calreticulin in human pregnancy with calreticulin in rat pregnancy, and to compare calreticulin during fetal growth restriction with normal control pregnancies. Methods Women were recruited who either had normal pregnancies or had pregnancies complicated with fetal growth restriction; maternal blood samples an..