Expanding the cleft phenotype: the dental characteristics of unaffected parents of Australian children with non-syndromic cleft lip and palate
Andrea Aspinall, Supriya Raj, Anil Jugessur, Mary Marazita, Ravi Savarirayan, Nicky Kilpatrick
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY | WILEY | Published : 2014
BACKGROUND: The aetiology of isolated clefts of the lip and/or palate remains obscure. Unaffected family members are treated as if their genetic risks are equivalent and low. Given the number of genes associated with both clefting and dental anomalies, the hypothesis that such anomalies contribute to the cleft phenotype should be explored. AIM: To describe the dental characteristics of parents of children with non-syndromic cleft lip ± palate. DESIGN: Unaffected parents of Australian children with a cleft of the lip ± palate underwent dental examination including radiographs, photographs, and impressions. Dental anomalies were identified. RESULTS: Data were available on 101 parents (49 males..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by United States National Institute of Health grant
Awarded by NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
This work was supported by the Victorian Government's Operational Infrastructure Support Program. OzCleft is funded by the National Health and Medical Research Council of Australia (grant no 607396) and by the United States National Institute of Health grant No R01-DE16148 (held by MM). Contents of the published material are solely the responsibility of the Administering Institution, individual authors, and do not reflect the views of NHMRC.