Journal article

Expanding the cleft phenotype: the dental characteristics of unaffected parents of Australian children with non-syndromic cleft lip and palate

Andrea Aspinall, Supriya Raj, Anil Jugessur, Mary Marazita, Ravi Savarirayan, Nicky Kilpatrick

INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY | WILEY | Published : 2014

Abstract

BACKGROUND: The aetiology of isolated clefts of the lip and/or palate remains obscure. Unaffected family members are treated as if their genetic risks are equivalent and low. Given the number of genes associated with both clefting and dental anomalies, the hypothesis that such anomalies contribute to the cleft phenotype should be explored. AIM: To describe the dental characteristics of parents of children with non-syndromic cleft lip ± palate. DESIGN: Unaffected parents of Australian children with a cleft of the lip ± palate underwent dental examination including radiographs, photographs, and impressions. Dental anomalies were identified. RESULTS: Data were available on 101 parents (49 males..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by United States National Institute of Health grant


Awarded by NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH


Funding Acknowledgements

This work was supported by the Victorian Government's Operational Infrastructure Support Program. OzCleft is funded by the National Health and Medical Research Council of Australia (grant no 607396) and by the United States National Institute of Health grant No R01-DE16148 (held by MM). Contents of the published material are solely the responsibility of the Administering Institution, individual authors, and do not reflect the views of NHMRC.