The regulation of mitochondrial DNA copy number in glioblastoma cells
A Dickinson, KY Yeung, J Donoghue, MJ Baker, RDW Kelly, M McKenzie, TG Johns, JC St John
CELL DEATH AND DIFFERENTIATION | NATURE PUBLISHING GROUP | Published : 2013
As stem cells undergo differentiation, mitochondrial DNA (mtDNA) copy number is strictly regulated in order that specialized cells can generate appropriate levels of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to undertake their specific functions. It is not understood whether tumor-initiating cells regulate their mtDNA in a similar manner or whether mtDNA is essential for tumorigenesis. We show that human neural stem cells (hNSCs) increased their mtDNA content during differentiation in a process that was mediated by a synergistic relationship between the nuclear and mitochondrial genomes and results in increased respiratory capacity. Differentiating multipotent g..View full abstract
Awarded by National Health and Medical Research Council
This work was supported by start up funds from Monash Institute of Medical Research to JCSJ, National Health and Medical Research Council (project grant no.: 1012020) and the Victorian Government's Operational Infrastructure Support Program. KYY was funded through a Medical Research Council, UK, PhD scholarship. MMcK is supported by an Australian Research Council Future Fellowship and the James and Vera Lawson Trust.