Increased decidual mRNA expression levels of candidate maternal preeclampsia susceptibility genes are associated with clinical severity
HEJ Yong, P Murthi, A Borg, B Kalionis, EK Moses, SP Brennecke, RJ Keogh
PLACENTA | W B SAUNDERS CO LTD | Published : 2014
INTRODUCTION: Pre-eclampsia (PE) has a familial association, with daughters of women who had PE during pregnancy having more than twice the risk of developing PE themselves. Through genome-wide linkage and genetic association studies in PE-affected families and large population samples, we previously identified the following as positional candidate maternal susceptibility genes for PE; ACVR1, INHA, INHBB, ERAP1, ERAP2, LNPEP, COL4A1 and COL4A2. The aims of this study were to determine mRNA expression levels of previously identified candidate maternal pre-eclampsia susceptibility genes from normotensive and severe PE (SPE) pregnancies and correlate mRNA expression levels with the clinical sev..View full abstract
Awarded by National Institutes of Health
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
The authors would like to thank the patients and clinical research midwives who were involved with sample donation and collection. This work was supported by funding from the Royal Women's Hospital, Parkville, Australia, the National Institutes of Health Grant HD049847 (to E.K. Moses and S.P. Brennecke). H.EJ. Yong was supported by the University of Melbourne's Melbourne International Fee Remission Scholarship and the Felix Meyer Scholarship in Obstetrics and Gynaecology.