Journal article
Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity
HEJ Yong, P Murthi, A Borg, B Kalionis, EK Moses, SP Brennecke, RJ Keogh
Placenta | Published : 2014
Abstract
Introduction Pre-eclampsia (PE) has a familial association, with daughters of women who had PE during pregnancy having more than twice the risk of developing PE themselves. Through genome-wide linkage and genetic association studies in PE-affected families and large population samples, we previously identified the following as positional candidate maternal susceptibility genes for PE; ACVR1, INHA, INHBB, ERAP1, ERAP2, LNPEP, COL4A1 and COL4A2. The aims of this study were to determine mRNA expression levels of previously identified candidate maternal pre-eclampsia susceptibility genes from normotensive and severe PE (SPE) pregnancies and correlate mRNA expression levels with the clinical seve..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
The authors would like to thank the patients and clinical research midwives who were involved with sample donation and collection. This work was supported by funding from the Royal Women's Hospital, Parkville, Australia, the National Institutes of Health Grant HD049847 (to E.K. Moses and S.P. Brennecke). H.EJ. Yong was supported by the University of Melbourne's Melbourne International Fee Remission Scholarship and the Felix Meyer Scholarship in Obstetrics and Gynaecology.