Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment
James F Markworth, Luke Vella, Benjamin S Lingard, Dedreia L Tull, Thusitha W Rupasinghe, Andrew J Sinclair, Krishna Rao Maddipati, David Cameron-Smith
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2013
Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control, and resolution of inflammation. Using a targeted lipidomics approach, we investigated circulating lipid mediator responses to resistance exercise and treatment with the NSAID ibuprofen. Human subjects undertook a single bout of unaccustomed resistance exercise (80% of one repetition maximum) following oral ingestion of ibuprofen (400 mg) or placebo control. Venous blood was collected during early recovery (0-3 h and 24 h postexercise), and serum lipid mediator composition was analyzed by LC-MS-based targeted ..View full abstract
Awarded by National Center for Research Resources, National Institutes of Health
Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES
This study was supported in part by National Center for Research Resources, National Institutes of Health Grant S10RR027926 (to K. R. Maddipati).