Journal article
Association between postnatal dexamethasone for treatment of bronchopulmonary dysplasia and brain volumes at adolescence in infants born very preterm
JLY Cheong, AC Burnett, KJ Lee, G Roberts, DK Thompson, SJ Wood, A Connelly, PJ Anderson, LW Doyle
Journal of Pediatrics | Published : 2014
Open access
Abstract
Objectives To compare brain volumes in adolescents who were born extremely preterm (<28 weeks gestation) who had received postnatal dexamethasone, and to determine if there was a postnatal dexamethasone dose-response effect on brain volumes. Study design Geographical cohort study of extremely preterm adolescents born in 1991-1992 in Victoria, Australia. T1-weighted magnetic resonance imaging was performed at 18 years of age. Segmented and parcellated brain volumes were calculated using an automated segmentation method (FreeSurfer) and compared between groups, with and without adjustment for potential confounders. The relationships between total postnatal dexamethasone dose and brain volumes ..
View full abstractGrants
Awarded by University of Melbourne
Funding Acknowledgements
Funded by Australian National Health and Medical Research Council (491246 to L.D., P.A., S.W., J.C.), Centre of Clinical Research Excellence (546519, Senior Research Fellowship 628371 [to P.A.], Early Career Fellowship 1053787 [to J.C.], Early Career Fellowship 1012236 [to D.T.], and Career Development Fellowship 1053609 [to K.L.]), and Victorian Government Operational Infrastructure Support Program. The authors declare no conflicts of interest.