Journal article
The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death
WA Figgett, K Fairfax, FB Vincent, MA LePage, I Katik, D Deliyanti, PS Quah, P Verma, R Grumont, S Gerondakis, P Hertzog, LA O'Reilly, A Strasser, F Mackay
Immunity | CELL PRESS | Published : 2013
Abstract
Activation-induced cell death (AICD) plays a critical role in immune homeostasis and tolerance. In T-cell-dependent humoral responses, AICD of Bcells is initiated by Fas ligand (FasL) on Tcells, stimulating the Fas receptor on B cells. In contrast, T-cell-independent B cell responses involve innate-type B lymphocytes, such as marginal zone (MZ) B cells, and little is known about the mechanisms that control AICD during innate B cell responses to Toll-like receptor (TLR) activation. Here, we show that MZ B cells undergo AICD in response to TLR4 activation invivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate e..
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Funding Acknowledgements
We thank C. Mackay, R. Brink, and S. Jane for critical reading of the manuscript; C. Brownlee and BTF staff (Garvan Institute), G. Paulkovics, J. Le Masurier (Monash AMREP flow cytometry), D. Saulep-Easton, M. Taylor, A. Lin, and R. Piganis for technical assistance; and S. Cody and I. Carmichael (Monash Micro Imaging). F. M., A. S., P. H., K. F., L.A.O'R., and S. G. are supported by grants and fellowships from the National Health and Medical Research Council and the Leukemia and Lymphoma Society of America and operational infrastructure grants through the Australian Government IRISS and the Victorian State Government OIS.