Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source
Caroline Deshayes, Shiva Kumar Angala, Estelle Marion, Irene Brandli, Jeremie Babonneau, Laurent Preisser, Sara Eyangoh, Yves Delneste, Pierre Legras, Chantal De Chastellier, Timothy P Stinear, Mary Jackson, Laurent Marsollier
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Mycobacterium ulcerans, a slow-growing environmental bacterium, is the etiologic agent of Buruli ulcer, a necrotic skin disease. Skin lesions are caused by mycolactone, the main virulence factor of M. ulcerans, with dermonecrotic (destruction of the skin and soft tissues) and immunosuppressive activities. This toxin is secreted in vesicles that enhance its biological activities. Nowadays, it is well established that the main reservoir of the bacilli is localized in the aquatic environment where the bacillus may be able to colonize different niches. Here we report that plant polysaccharides stimulate M. ulcerans growth and are implicated in toxin synthesis regulation. METHODOLOGY/..View full abstract
Awarded by Agence Nationale de la Recherche
Awarded by ANR
This study was supported by the Fondation Raoul Follereau (http://www.raoul-follereau.org/), the Institut National de la Sante et de la Recherche Medicale (Inserm, Programme Inserm Avenir)(http://www.inserm.fr/); Agence Nationale de la Recherche (ANR 11 CEPL 007 (EXTRA-MU))(http://www.agence-nationale-recherche.fr/), institutional grants from the University of Angers (http://www.univ-angers.fr/), Region Pays de la Loire (ARMINA project)(http://www.paysdelaloire.fr/). CD is funded by post-doctoral grants from Conseil General Maine-et-Loire (http://www.cg49.fr/) and Angers Loire Metropole (http://www.angersloiremetropole.fr/) and Axa Research Fund (http://www.axa-research.org/) and ANR 11 CEPL 007 (EXTRA-MU). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.