Proteomic Analysis of the Excretory-Secretory Products from Larval Stages of Ascaris suum Reveals High Abundance of Glycosyl Hydrolases
Tao Wang, Katleen Van Steendam, Maarten Dhaenens, Johnny Vlaminck, Dieter Deforce, Aaron R Jex, Robin B Gasser, Peter Geldhof
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different phases of tissue invasion and migration are likely to play critical roles in the induction and development of protective immune and other host responses. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this study was to identify the ES proteins of the different larval stages (L3-egg, L3-lung and L4) by LC-MS/MS. In total, 106 different proteins were identified, 20 in L3-egg, 45 in L3-lung stage and 58 in L4. Although most of the proteins identifi..View full abstract
The work was supported through funding of China Scholarship Council and Special Research Fund (BOF) of Ghent University (Belgium). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.