Headache after lumbar puncture: Randomised crossover trial of 22-gauge versus 25-gauge needles

Abstract

Objectives To compare the frequency of headache and the procedure time following lumbar puncture (LP) using a 25-gauge needle compared to a 22-gauge needle. Design 4-period crossover blinded randomised controlled trial. Setting Oncology unit, Royal Children's Hospital, Melbourne. Patients Children aged 4-15 years at enrolment having LPs as part of their treatment for leukaemia. Interventions Each child was allocated a random sequence of four LPs, two with a 22-gauge and two with a 25-gauge needle. Outcome measures The presence of post-LP headache. Secondary outcomes included the presence of any headache, procedure time and impact of headache on the family. Results Data on 341 procedures in 9..