Journal article

Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999-2011

Eugene Ong, Raph Goldacre, Hoang Uy, Rodney Sinclair, Michael Goldacre



We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculated standardised rate ratios (RRs) based on person-years at risk, comparing the observed and expected numbers of BP cases in the cancer cohort with those in the reference cohort. Overall, the cohort of people with a record of a malignant cancer was not found to be at greater risk of concurrent or subsequent BP than the cohort of people without a record of a malignant cancer (RR 0..

View full abstract


Awarded by English National Institute for Health Research

Funding Acknowledgements

Over many years, the linked data-files were built by Leicester Gill and Matt Davidson, Unit of Health-Care Epidemiology (UHCE), University of Oxford. David Yeates (UHCE) wrote the software package used for the analysis. The Unit of Health-Care Epidemiology is funded by the English National Institute for Health Research to analyse the linked data (Grant reference number RNC/035/002). The views expressed in this paper do not necessarily reflect those of the funding body.