Poromechanical stimulation of bone remodeling: A continuum micromechanics-based mathematical model and experimental validation

Abstract

Bone tissue is a living biological entity. In particular, it is able to renew itself, which is key for maintaining its mechanical integrity necessary for fulfilling fundamental tasks such as providing protection of organs and facilitating locomotion. Moreover, bone is also able to accommodate to a long-term changing mechanical loading (as it may occur during exercise regimes, bedrest, or exposure to microgravity). The process responsible for accomplishing either task is termed bone remodeling, involving removal of mature bone tissue and subsequent formation of new bone tissue. Bone remodeling is driven by complex actions of biological cells and biochemical factors, and it is sensitive to the..