Motility changes induced by intraluminal FeSO4 in guinea pig jejunum
K Wang, RL Bertrand, S Senadheera, KE Polglaze, TV Murphy, SL Sandow, L Liu, JC Bornstein, PP Bertrand
Neurogastroenterology and Motility | WILEY | Published : 2014
BACKGROUND: Dietary iron supplementation is associated with gastrointestinal (GI) side effects including vomiting, nausea, and diarrhea. Although inorganic iron in high concentrations may be damaging to the intestinal mucosa, we hypothesize that there are physiological effects on the GI tract that occur at concentrations achieved by supplementation. Thus, our aim was to investigate the effect of intraluminal ferrous sulfate (FeSO4 ) on jejunal motility. METHODS: Segments of guinea pig jejunum were cannulated and the intraluminal pressure recorded with a transducer, while movements were recorded with a video camera. Peristaltic threshold was the oral pressure that evoked four consecutive prop..View full abstract
Related Projects (1)
Awarded by NHMRC (Australia)
This study was supported by the NHMRC (Australia) grant #510202 (PPB), #APP1048885 (LL and PPB), #566642 (JCB and PPB) and #401112, #455243 (SLS).