Journal article
A tale of two maladies? Pathogenesis of depression with and without the Huntington's disease gene mutation
X Du, TYC Pang, AJ Hannan
Frontiers in Neurology | Published : 2013
Abstract
Huntington's disease (HD) is an autosomal dominant disorder caused by a tandem repeat expansion encoding an expanded tract of glutamines in the huntingtin protein. HD is progressive and manifests as psychiatric symptoms (including depression), cognitive deficits (culminating in dementia), and motor abnormalities (including chorea). Having reached the twentieth anniversary of the discovery of the "genetic stutter" which causes HD, we still lack sophisticated insight into why so many HD patients exhibit affective disorders such as depression at very early stages, prior to overt appearance of motor deficits. In this review, we will focus on depression as the major psychiatric manifestation of H..
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Awarded by ARC
Funding Acknowledgements
We gratefully acknowledge the support of NHMRC Project Grants and an ARC Future Fellowship FT3 (Anthony J. Hannan), as well as a University of Melbourne Research Scholarship (Xin Du). We thank past and present members of the Hannan Laboratory for useful discussions and data that have informed the writing of this manuscript.