Journal article
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
J Galon, B Mlecnik, G Bindea, HK Angell, A Berger, C Lagorce, A Lugli, I Zlobec, A Hartmann, C Bifulco, ID Nagtegaal, R Palmqvist, GV Masucci, G Botti, F Tatangelo, P Delrio, M Maio, L Laghi, F Grizzi, M Asslaber Show all
Journal of Pathology | Published : 2014
DOI: 10.1002/path.4287
Abstract
The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of co..
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Awarded by European Commission
Funding Acknowledgements
We acknowledge all the scientists who made contributions to the area of research reviewed here that were not cited due to space constraints. The work performed in the Laboratory of Integrative Cancer Immunology and the immunomonitoring platform of the HEGP hospital was supported by grants from the Institut National du Cancer, France (INCa), Assistance Publique-Hopitaux de Paris, the national PHRC programme IMMUCOL, the Canceropole Ile de France, INSERM, MedImmune, Qatar National Research Fund under its National Priorities Research Programme (Award No. NPRP09-1174-3-291), the European Commission (7FP, Geninca Consortium; Grant No. 202230), Cancer Research for Personalized Medicine (CARPEM) and the LabEx Immuno-oncology. The authors wish to acknowledge the following organizations for supporting the Immunoscore following the WIC meeting: Society for Immunotherapy of Cancer (SITC); the European Academy of Tumour Immunology (EATI); La Fondazione Melanoma Onlus; National Cancer Institute, USA (NCI); Biotherapy Development Association (BDA); Canadian Cancer Immunotherapy Consortium (CCIC); Cancer Immunotherapy Consortium (CIC); Cancer Research Institute (CRI); Association for Cancer Immunotherapy (CIMT); Committee for Tumour Immunology and Biotherapy (TIBT); European Society for Cancer Immunology and Immunotherapy (ESCII); Italian Network for Tumour Biotherapy (NIBIT); Japanese Association of Cancer Immunology (JACI); Nordic Centre for Development of Antitumour Vaccines (NCV-Network); Progress in Vaccination Against Cancer (PIVAC); Adoptive engineered T cell Targeting to Activate Cancer Killing (ATTACK); Tumour Vaccine and Cell Therapy Working Group (TVACT); and Institut National du Cancer, France (INCa).