Journal article

A Genomics-Based Classification of Human Lung Tumors

Danila Seidel, Thomas Zander, Lukas C Heukamp, Martin Peifer, Marc Bos, Lynnette Fernandez-Cuesta, Frauke Leenders, Xin Lu, Sascha Ansen, Masyar Gardizi, Chau Nguyen, Johannes Berg, Prudence Russell, Zoe Wainer, Hans-Ulrich Schildhaus, Toni-Maree Rogers, Benjamin Solomon, William Pao, Scott L Carter, Gad Getz Show all

Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2013

Abstract

We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration potentially amenable to specific therapeutic intervention, including several personalized treatment approaches that are already in clinical evaluation. Marked differences in the pattern of genomic alterations existed between and within histological subtypes, thus challenging the original histomorphological diagnosis. Immunohistochemical studies confirmed many of these reassigned subtypes. The reassignment eliminated almost all cases of large cell carc..

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Grants

Awarded by EU-Framework Programme CURELUNG


Awarded by Deutsche Forschungsgemeinschaft


Awarded by German Ministry of Science and Education as part of the NGFNplus program


Awarded by Behrens-Weise Foundation (M.I.F.A.)


Awarded by Stand Up To Cancer-American Association for Cancer Research Innovative Research Grant


Awarded by German Centre for Lung Research


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by the EU-Framework Programme CURELUNG (HEALTH-F2-2010-258677 to R. K. T., R. B., and J.W.), by the Deutsche Forschungsgemeinschaft through TH1386/3-1 (to R. K. T. and M. L. S.) and through SFB832 (TP6 to R. K. T. and J.W.; TP5 to L. C. H.) and SB680 (to J.B.), by the German Ministry of Science and Education as part of the NGFNplus program (grant 01GS08100 to R. K. T. and J.W.; grant 01GS08101 to P.N.), by the Deutsche Krebshilfe as part of the Oncology Centers of Excellence funding program (to R. K. T., R. B., and J.W.) and SyBaCol (to J.B.), by the Max Planck Society, by the Behrens-Weise Foundation (M.I.F.A. NEUR8061 to R. K. T.), by Stand Up To Cancer-American Association for Cancer Research Innovative Research Grant (SU2C-AACR-IR60109 to W. P. and R. K. T.), by the Roy Castle Lung Cancer Foundation UK (to J.K.F.), and by an anonymous foundation (to R. K. T.). T. M. was supported by 82DZL00402 (DZL biobank platform) from the German Centre for Lung Research. Funding of supercomputer CHEOPS was provided by the DFG and the Ministry of Research of the State of North Rhine-Westphalia.