Gene-based urinary biomarkers for bladder cancer: An unfulfilled promise?
Nikhil Sapre, Paul D Anderson, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | ELSEVIER SCIENCE INC | Published : 2014
OBJECTIVE: Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytology. Gene-based testing has shown great promise for biomarker profiling and this review addresses the current state of biomarker research in bladder cancer. MATERIALS AND METHODS: A comprehensive review of all published literature on urinary biomarkers from 1970 - 2012 was conducted in PubMed. Keywords used alone or in combination were bladder cancer, diagnosis, surveillance, urinary biomarker, molecular b..View full abstract
N.S. is supported by postgraduate scholarships from the Royal Australasian College of Surgeons, Cancer Council Victoria, and the Cybec Cancer Research Foundation.