A Novel Approach for Prediction of Vitamin D Status Using Support Vector Regression
Shuyu Guo, Robyn M Lucas, Anne-Louise Ponsonby
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Epidemiological evidence suggests that vitamin D deficiency is linked to various chronic diseases. However direct measurement of serum 25-hydroxyvitamin D (25(OH)D) concentration, the accepted biomarker of vitamin D status, may not be feasible in large epidemiological studies. An alternative approach is to estimate vitamin D status using a predictive model based on parameters derived from questionnaire data. In previous studies, models developed using Multiple Linear Regression (MLR) have explained a limited proportion of the variance and predicted values have correlated only modestly with measured values. Here, a new modelling approach, nonlinear radial basis function support ve..View full abstract
Dr. Guo is funded by an Australian Postgraduate Award. Prof. Lucas is funded by a National Health and Medical Research (NHMRC) Career Development Fellowship and receives research funding from Cancer Australia, NHMRC, and MS Research Australia. Prof. Ponsonby is funded by a NHMRC Research Fellowship and receives research funding from NHMRC and MS Research Australia. The Ausimmune Study was funded by the US National Multiple Sclerosis Society, NHMRC, and MS Research Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.