Journal article
IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
TJ Urban, AJ Thompson, SS Bradrick, J Fellay, D Schuppan, KD Cronin, L Hong, A McKenzie, K Patel, KV Shianna, JG McHutchison, DB Goldstein, N Afdhal
Hepatology | Published : 2010
DOI: 10.1002/hep.23912
Abstract
Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon-α and ribavirin. We hypothesized that IL28B polymorphism is associated with intrahepatic expression of interferon-stimulated genes (ISGs), known to influence treatment outcome. IL28B genotyping (rs12979860) and whole-genome RNA expression were performed using liver biopsies from 61 North American patients with CHC. After correction for multiple testing (false discovery rate < 0.10), 164 transcripts were found to be differentially expressed by IL28B-type. The interferon si..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
Part of this work was supported by the National Institutes of Health grant NIH U19 AI066313 Hepatitis C Cooperative Research Centers to D S and N H A