Journal article
The role of viral and host genetics in natural history and treatment of chronic HCV infection
JS Doyle, ME Hellard, AJ Thompson
Best Practice and Research Clinical Gastroenterology | Published : 2012
Abstract
Understanding of the natural history and treatment responsiveness of chronic hepatitis C virus (HCV) infection has evolved rapidly in recent years. Advances in HCV molecular virology and host genetics can now better predict spontaneous clearance and treatment outcomes. HCV genotype is the most important viral factor predicting interferon-α treatment responsiveness; HCV-1 subtype is emerging as a key determinant of the efficacy of direct acting antiviral therapy. Genome-wide association studies have recently identified several clinically important host determinants of the outcomes of peginterferon-α and ribavirin treatment outcome: IL28B polymorphism is associated with spontaneous clearance a..
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Funding Acknowledgements
[ "JD, AT and MH acknowledges fellowship support from the National Health and Medical Research Council (NHMRC). JD and MH acknowledge the contribution to this work of the NHMRC Centre for Research Excellence in Injecting Drug Use and the Victorian Operational Infrastructure Support Program (Department of Health, Victoria, Australia) to the Burnet Institute.", "MH: Research support - Roche.", "AT: Research/grant support - Merck, Roche Pharmaceuticals, Gilead Sciences; Consulting/advisory capacity - Merck, Roche Pharmaceuticals, Janssen-Cilag (Johnson and Johnson); Speaker's fee - Merck, Roche Pharmaceuticals, Bristol-Myers Squibb. Co-inventor of a patent related to the IL28B HCV discovery." ]