Journal article
Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial
Susan E Jacobs, Jacinta M Tobin, Gillian F Opie, Susan Donath, Sepehr N Tabrizi, Marie Pirotta, Colin J Morley, Suzanne M Garland
PEDIATRICS | AMER ACAD PEDIATRICS | Published : 2013
Abstract
BACKGROUND AND OBJECTIVE: Late-onset sepsis frequently complicates prematurity, contributing to morbidity and mortality. Probiotics may reduce mortality and necrotizing enterocolitis (NEC) in preterm infants, with unclear effect on late-onset sepsis. This study aimed to determine the effect of administering a specific combination of probiotics to very preterm infants on culture-proven late-onset sepsis. METHODS: A prospective multicenter, double-blinded, placebo-controlled, randomized trial compared daily administration of a probiotic combination (Bifidobacterium infantis, Streptococcus thermophilus, and Bifidobacterium lactis, containing 1 × 10(9) total organisms) with placebo (maltodextrin..
View full abstractGrants
Awarded by National Health and Research Medical Council of Australia
Funding Acknowledgements
Supported by the National Health and Research Medical Council of Australia (project grant 454629), The Royal Women's Hospital Foundation, Melbourne, Australia, and The Angior Family Foundation, Melbourne, Australia.