Impaired Response Inhibition Is Associated With Self-Reported Symptoms of Depression, Anxiety, and ADHD in Female FMR1 Premutation Carriers
Claudine M Kraan, Darren R Hocking, Nellie Georgiou-Karistianis, Sylvia A Metcalfe, Alison D Archibald, Joanne Fielding, Julian Trollor, John L Bradshaw, Jonathan Cohen, Kim M Cornish
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | WILEY | Published : 2014
Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age- and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social an..View full abstract
Related Projects (1)
Awarded by Australian Research Council (ARC) Discovery
Grant sponsor: Australian Research Council (ARC) Discovery; Grant number: DP110103346; Grant sponsor: Monash University Research Fellowship; Grant sponsor: National Fragile X Foundation Rosen Summer Student Fellowship Award; Grant sponsor: Australian Postgraduate Award Scholarship Scheme; Grant sponsor: Victorian Government's Operational Infrastructure Support Program.