Journal article
Patients with single distal MCA perfusion lesions have a high rate of good outcome with or without reperfusion
R Lemmens, S Christensen, M Straka, DA De Silva, M Mlynash, BCV Campbell, R Bammer, JM Olivot, P Desmond, MP Marks, SM Davis, GA Donnan, GW Albers, MG Lansberg
International Journal of Stroke | WILEY-BLACKWELL | Published : 2014
DOI: 10.1111/ijs.12230
Abstract
Background: Reperfusion is associated with good functional outcome after stroke. However, minimal data are available regarding the effect of reperfusion on clinical outcome and infarct growth in patients with distal MCA branch occlusions. Aim: The aim of this study was to evaluate this association and to determine the impact of the perfusion-diffusion mismatch. Methods: Individual patient data from three stroke studies (EPITHET, DEFUSE and DEFUSE 2) with baseline MRI profiles and reperfusion status were pooled. Patients were included if they had a single cortical perfusion lesion on their baseline MRI that was consistent with a distal MCA branch occlusion. Good functional outcome was defined..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
The DEFUSE study was supported by the National Institutes of Health (NINDS, RO1 NS39325; K24 NS044848). The EPITHET study was supported by National Health and Medical Research Council, Australia; National Stroke Foundation, Australia; Heart Foundation of Australia. The DEFUSE 2 study was supported by the National Institutes of Health (NINDS, K23 NS051372; R01 NS03932505). R. L. is a senior clinical investigator of FWO Flanders.