Journal article
Peripheral blood involvement in patients with follicular lymphoma: A rare disease manifestation associated with poor prognosis
C Sarkozy, L Baseggio, P Feugier, E Callet-Bauchu, L Karlin, JF Seymour, L Lebras, AS Michallet, F Offner, O Dumas, A Traverse-Glehen, M Ffrench, A Lopez-Guillermo, F Berger, B Coiffier, P Felman, G Salles
British Journal of Haematology | Published : 2014
DOI: 10.1111/bjh.12675
Abstract
Summary: Follicular Lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL) subtype and its course is heterogeneous. At diagnosis, some patients with FL manifest a detectable leukaemic phase (FL-LP), but this feature has been seldom described and is poorly characterized. Among 499 patients diagnosed with FL in Lyon-Sud hospital, 37 (7·4%) had characteristic FL-LP (by cytological blood smears and flow cytometric analysis). In addition, 91/1135 FL patients from the PRIMA study presented FL-LP at study entry. In order to evaluate the outcome of this Lyon-Sud cohort, FL-LP patients were matched with 111 newly diagnosed FL without LP according to the Follicular Lymphoma International P..
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