Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules

Kang Liang; Georgina K Such; Angus PR Johnston; Zhiyuan Zhu; Hirotaka Ejima; Joseph J Richardson; Jiwei Cui; Frank Caruso

Journal article

Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules

Kang Liang, Georgina K Such, Angus PR Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso

ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2014

DOI: 10.1002/adma.201305144

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Abstract

The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.

University of Melbourne Researchers

Frank Caruso Author Chemical Engineering

Georgina Such Author Chemistry

Jiwei Cui Author Chemical Engineering

Jj Richardson Author Chemical Engineering

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Australian Laureate Fellowship FL120100030 (F. C.), Discovery Project DP0877360 (F. C.), Super Science Fellowship FS110200025 (F. C.), and Australian Future Fellowship FT120100564 (G. K. S.) and FT110100265 (A.P.R.J.) schemes.