A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: Three-year results

Abstract

Purpose To report the refractive, topographic, and clinical outcomes 3 years after corneal collagen cross-linking (CXL) in eyes with progressive keratoconus. Design Prospective, randomized controlled trial. Participants One hundred eyes with progressive keratoconus were randomized into the CXL treatment or control groups. Methods Cross-linking was performed by instilling riboflavin 0.1% solution containing 20% dextran for 15 minutes before and during the 30 minutes of ultraviolet A irradiation (3 mW/cm2). Follow-up examinations were arranged at 3, 6, 12, 24, and 36 months. Main Outcome Measures The primary outcome measure was the maximum simulated keratometry value (K max). Other outcome mea..