Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles
Kang Liang, Joseph J Richardson, Hirotaka Ejima, Georgina K Such, Jiwei Cui, Frank Caruso
ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2014
A novel class of nanoparticles is developed for the co-delivery of a short cell penetrating peptide and a chemotherapeutic drug to achieve enhanced cytotoxicity. Tunable cytotoxicity is achieved through non-toxic peptide-facilitated gating. The strategy relies on a one-step blending process from polymer building blocks to form monodisperse, PEGylated particles that are sensitive to cellular pH variations. By varying the amount of peptide loading, the chemotherapeutic effects can be enhanced by up to 30-fold.
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Awarded by Australian Research Council
This work was supported by Australian Research Council under the Australian Laureate Fellowship FL120100030 (F. C.), Discovery Project DP0877360 (F. C.), Super Science Fellowship FS110200025 (F. C.), and Australian Future Fellowship FT120100564 (G. K. S.) schemes.